• Target：
• TALDO

• Fields：
• >>Pentose phosphate pathway;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids

• Gene Name：
• TALDO1 TAL TALDO TALDOR

• Protein Name：
• TALDO

• Human Gene Id：
• 6888

• Human Swiss Prot No：
• P37837

• Mouse Gene Id：
• 21351

• Mouse Swiss Prot No：
• Q93092

• Rat Gene Id：
• 83688

• Rat Swiss Prot No：
• Q9EQS0

• Immunogen：
• Synthesized peptide derived from human TALDO AA range: 21-71

• Specificity：
• This antibody detects endogenous levels of TALDO at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 37kD

• Background：
• Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.,disease:Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency) [MIM:606003]. It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris.,function:Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.,pathway:Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.,similarity:Belongs to the transaldolase family.,similarity:Belongs to the transaldolase family. Type 1 subfamily.,

• Subcellular Location：
• Cytoplasm .

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