• Target：
• ATS6

• Gene Name：
• ADAMTS6

• Protein Name：
• ATS6

• Human Gene Id：
• 11174

• Human Swiss Prot No：
• Q9UKP5

• Immunogen：
• Synthesized peptide derived from human ATS6 AA range: 989-1039

• Specificity：
• This antibody detects endogenous levels of ATS6 at Human

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 123kD

• Background：
• This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016],

• Function：
• cofactor:Binds 1 zinc ion per subunit.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,induction:Isoform 1 and 2 expressions are up-regulated by TNF-alpha in retinal pigment epithelial cells.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed at low levels in placenta and barely detectable in a number of other tissues.,

• Subcellular Location：
• Secreted, extracellular space, extracellular matrix .

• Expression：
• Expressed at low levels in placenta and barely detectable in a number of other tissues.

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