• Target：
• KBTBA

• Gene Name：
• KBTBD10 KRP1

• Protein Name：
• KBTBA

• Human Gene Id：
• 10324

• Human Swiss Prot No：
• O60662

• Rat Gene Id：
• 117537

• Rat Swiss Prot No：
• Q9ER30

• Immunogen：
• Synthesized peptide derived from human KBTBA AA range: 268-318

• Specificity：
• This antibody detects endogenous levels of KBTBA at Human/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 67kD

• Background：
• This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015],

• Function：
• function:Required for pseudopod elongation in transformed cells. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated and probably targeted for proteasome-independent degradation.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 5 Kelch repeats.,subcellular location:Predominantly cytoplasmic but can co-localize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia.,subunit:Interacts with NRAP (By similarity). Part of a complex that contains CUL3, RBX1 and KBTBD10.,tissue specificity:Sarcomeric muscle.,

• Subcellular Location：
• Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, pseudopodium . Cell projection, ruffle . Cytoplasm, myofibril, sarcomere, M line . Sarcoplasmic reticulum membrane . Endoplasmic reticulum membrane . Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia. .

• Expression：
• Sarcomeric muscle.

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