- Target:
- C8AP2
- Gene Name:
- CASP8AP2 FLASH KIAA1315 RIP25
- Protein Name:
- C8AP2
- Human Gene Id:
- 9994
- Human Swiss Prot No:
- Q9UKL3
- Mouse Gene Id:
- 26885
- Mouse Swiss Prot No:
- Q9WUF3
- Immunogen:
- Synthesized peptide derived from human C8AP2 AA range: 1155-1205
- Specificity:
- This antibody detects endogenous levels of C8AP2 at Human/Mouse
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 218kD
- Background:
- This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008],
- Function:
- function:Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.,induction:By TNF-alpha, which induces strong nuclear localization.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 364.,subcellular location:Localizes to discrete nuclear foci.,subunit:Self-associates. Component of the death-inducing signalin
- Subcellular Location:
- Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Exported from the nucleus to the mitochondria upon FAS activation.
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night