• Target：
• C8AP2

• Gene Name：
• CASP8AP2 FLASH KIAA1315 RIP25

• Protein Name：
• C8AP2

• Human Gene Id：
• 9994

• Human Swiss Prot No：
• Q9UKL3

• Mouse Gene Id：
• 26885

• Mouse Swiss Prot No：
• Q9WUF3

• Immunogen：
• Synthesized peptide derived from human C8AP2 AA range: 1155-1205

• Specificity：
• This antibody detects endogenous levels of C8AP2 at Human/Mouse

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 218kD

• Background：
• This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008],

• Function：
• function:Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.,induction:By TNF-alpha, which induces strong nuclear localization.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 364.,subcellular location:Localizes to discrete nuclear foci.,subunit:Self-associates. Component of the death-inducing signalin

• Subcellular Location：
• Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Exported from the nucleus to the mitochondria upon FAS activation.

Downregulating CREBBP inhibits proliferation and cell cycle progression and induces daunorubicin resistance in leukemia cells. Molecular Medicine Reports Mol Med Rep. 2020 Oct;22(4):2905-2915 WB Human 1:500 Jurkat cell， Reh cell

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