FUT1 rabbit pAb
- Catalog No.:YT6360
- Applications:WB
- Reactivity:Human;Mouse;Rat
- Target:
- FUT1
- Fields:
- >>Glycosphingolipid biosynthesis - lacto and neolacto series;>>Glycosphingolipid biosynthesis - globo and isoglobo series;>>Metabolic pathways
- Gene Name:
- FUT1 H HSC
- Protein Name:
- FUT1
- Human Gene Id:
- 2523
- Human Swiss Prot No:
- P19526
- Mouse Swiss Prot No:
- O09160
- Rat Gene Id:
- 81919
- Rat Swiss Prot No:
- Q10980
- Immunogen:
- Synthesized peptide derived from human FUT1 AA range: 150-200
- Specificity:
- This antibody detects endogenous levels of FUT1 at Human/Mouse/Rat
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500-2000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Molecular Weight(Da):
- 40kD
- Background:
- This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016],
- Function:
- catalytic activity:GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.,function:Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.,miscellaneous:There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.,online information:Blood group antigen gene mutation database,online
- Subcellular Location:
- Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Membrane-bound form in trans cisternae of Golgi. .
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- Antibody-FAQs
- Products Images
- Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°over night