• Target：
• DEGS2

• Fields：
• >>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway

• Gene Name：
• DEGS2 C14orf66

• Protein Name：
• DEGS2

• Human Gene Id：
• 123099

• Human Swiss Prot No：
• Q6QHC5

• Mouse Gene Id：
• 70059

• Mouse Swiss Prot No：
• Q8R2F2

• Rat Gene Id：
• 314438

• Rat Swiss Prot No：
• Q564G3

• Immunogen：
• Synthesized peptide derived from human DEGS2 AA range: 92-142

• Specificity：
• This antibody detects endogenous levels of DEGS2 at Human/Mouse/Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1：500-2000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 36kD

• Background：
• This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008],

• Function：
• function:Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase.,induction:Up-regulated during keratinocyte differentiation. Not expressed at day 0 or day 3 after differentiation, detected on day 6 and increases by day 9.,pathway:Membrane lipid metabolism; sphingolipid biosynthesis.,similarity:Belongs to the fatty acid desaturase family. DEGS subfamily.,tissue specificity:Highly expressed in skin, intestine and kidney.,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Multi-pass membrane protein .

• Expression：
• Highly expressed in skin, intestine and kidney.

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