• Target：
• POLD4

• Fields：
• >>DNA replication;>>Base excision repair;>>Nucleotide excision repair;>>Mismatch repair;>>Homologous recombination

• Gene Name：
• POLD4 POLDS

• Protein Name：
• POLD4

• Human Gene Id：
• 57804

• Human Swiss Prot No：
• Q9HCU8

• Immunogen：
• Synthesized peptide derived from human POLD4 AA range: 43-93

• Specificity：
• This antibody detects endogenous levels of human POLD4

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12)

• Molecular Weight(Da)：
• 12kD

• Background：
• This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],

• Function：
• function:Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.,similarity:Belongs to the DNA polymerase delta subunit 4 family.,subunit:Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD4, POLD2, POLD1 and PCNA.,

• Subcellular Location：
• Nucleus . Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. .

• Expression：
• Brain,Cervix,Ovarian carcinoma,Pooled,

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