Caspase-8 Polyclonal Antibody

  • Catalog No.:YT6191
  • Applications:IHC-p,WB
  • Reactivity:Human, Mouse, Rat
  • Description
  • Gene Name:
  • CASP8 MCH5
  • Protein Name:
  • Caspase-8
  • Human Gene Id:
  • 841
  • Human Swiss Prot No:
  • Q14790
  • Immunogen:
  • Synthesized peptide derived from human Caspase-8
  • Specificity:
  • This antibody detects endogenous levels of human Caspase-8
  • Formulation:
  • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source:
  • Rabbit
  • Dilution:
  • IHC-p 1:50-200, WB 1:500-2000
  • Purification:
  • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration:
  • 1 mg/ml
  • Storage Stability:
  • -20°C/1 year
  • Other Name:
  • Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MOR
  • Observed Band(KD):
  • 55
  • Background:
  • CASP8 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD. Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
  • Function:
  • angiogenesis, blood vessel development, embryonic epithelial tube formation, neural tube formation, vasculature development, morphogenesis of an epithelium, immune system development, leukocyte differentiation, myeloid leukocyte differentiation, protein complex assembly, proteolysis, apoptosis, induction of apoptosis, heart development, cell death, induction of apoptosis by extracellular signals, activation of pro-apoptotic gene products,macromolecule catabolic process, embryonic development ending in birth or egg hatching, positive regulation of signal transduction, response to organic substance, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, positive regulation of cell death,programmed cell death, induction of programmed cell death, death, morphogenesis of embryonic epithelium, ne