Granzyme M Polyclonal Antibody
- Catalog No.:YT6049
- Applications:IHC;IF;ELISA
- Reactivity:Human;Rat
- Target:
- Granzyme M
- Gene Name:
- GZMM MET1
- Protein Name:
- Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)
- Human Gene Id:
- 3004
- Human Swiss Prot No:
- P51124
- Immunogen:
- Synthetic peptide from human protein at AA range: 207-256
- Specificity:
- The antibody detects endogenous Granzyme M
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Granzyme M (EC 3.4.21.-;Met-1 serine protease;Hu-Met-1;Met-ase;Natural killer cell granular protease)
- Background:
- Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
- Function:
- function:Cleaves peptide substrates after methionine, leucine, and norleucine.,similarity:Belongs to the peptidase S1 family. Granzyme subfamily.,similarity:Contains 1 peptidase S1 domain.,subcellular location:Granules of large granular lymphocytes.,
- Subcellular Location:
- Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.
- Expression:
- Highly and constitutively expressed in activated natural killer (NK) cells.
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- Antibody-FAQs
- Products Images
- Immunohistochemical analysis of paraffin-embedded Human-lymph, antibody was diluted at 1:100
- Immunohistochemical analysis of paraffin-embedded Human-lymph, antibody was diluted at 1:100