GRB7 Polyclonal Antibody
- Catalog No.:YT6020
- Applications:IHC;IF;ELISA
- Reactivity:Human;Mouse;Rat
- Target:
- GRB7
- Gene Name:
- GRB7
- Protein Name:
- Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
- Human Gene Id:
- 2886
- Human Swiss Prot No:
- Q14451
- Mouse Gene Id:
- 14786
- Mouse Swiss Prot No:
- Q03160
- Immunogen:
- Synthetic peptide from human protein at AA range: 30-100
- Specificity:
- The antibody detects endogenous GRB7
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Growth factor receptor-bound protein 7 (B47;Epidermal growth factor receptor GRB-7;GRB7 adapter protein)
- Background:
- The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011],
- Function:
- alternative products:At least 2 isoforms are produced,function:Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the GRB7/10/14 family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with RND1.,
- Subcellular Location:
- Cytoplasm . Cell junction, focal adhesion . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic granule . Cell projection . Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions. .
- Expression:
- Liver,Lung,Oesophageal carcinoma,Thalamus,
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- Antibody-FAQs
- Products Images
- Immunohistochemical analysis of paraffin-embedded Human-breast, antibody was diluted at 1:100