ST2 Polyclonal Antibody
- Catalog No.:YT5992
- Applications:WB;IHC;IF;ELISA
- Reactivity:Human;Rat;Mouse;
- Target:
- ST2
- Fields:
- >>Cytokine-cytokine receptor interaction
- Gene Name:
- IL1RL1 DER4 ST2 T1
- Protein Name:
- Interleukin-1 receptor-like 1 (Protein ST2)
- Human Gene Id:
- 9173
- Human Swiss Prot No:
- Q01638
- Mouse Gene Id:
- 17082
- Mouse Swiss Prot No:
- P14719
- Immunogen:
- Synthetic peptide from human protein at AA range: 251-300
- Specificity:
- The antibody detects endogenous ST2
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Interleukin-1 receptor-like 1 (Protein ST2)
- Molecular Weight(Da):
- 63kD
- Background:
- The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008],
- Function:
- function:Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYD88, IRAK1, IRAK4, and TRAF6.,tissue specificity:Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Expression of isoform A is prevalent in the lung, testis, placenta, stomach and colon. However, isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.,
- Subcellular Location:
- [Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane ; Single-pass type I membrane protein .
- Expression:
- Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. BMC INFECTIOUS DISEASES 2016 May 16 ELISA Human Sera
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- Antibody-FAQs
- Products Images
- Zhang, Zhihui, et al. "Serum levels of soluble ST2 and IL-10 are associated with disease severity in patients with IgA nephropathy." Journal of immunology research 2016 (2016).
- Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200