• Gene Name：
• IL1RL1

• Protein Name：
• Interleukin-1 receptor-like 1

• Human Gene Id：
• 9173

• Human Swiss Prot No：
• Q01638

• Mouse Swiss Prot No：
• P14719

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• IL1RL1;DER4;ST2;T1;Interleukin-1 receptor-like 1;Protein ST2

• Detection Method：
• Colorimetric

• Background：
• function:Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYD88, IRAK1, IRAK4, and TRAF6.,tissue specificity:Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Expression of isoform A is prevalent in the lung, testis, placenta, stomach and colon. However, isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.,

• Function：
• defense response, immune response, negative regulation of signal transduction, regulation of protein kinase cascade,negative regulation of cell communication, negative regulation of protein kinase cascade, regulation of I-kappaB kinase/NF-kappaB cascade, negative regulation of I-kappaB kinase/NF-kappaB cascade, innate immune response,

• Subcellular Location：
• [Isoform C]: Cell membrane.; [Isoform B]: Secreted.; Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.

Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy. Journal of Immunology Research J Immunol Res. 2016;2016:6540937 ELISA Human sera

Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. BMC INFECTIOUS DISEASES 2016 May 16 ELISA Human Sera

Serum ST2 in inflammatory bowel disease: a potential biomarker for disease activity. JOURNAL OF INVESTIGATIVE MEDICINE J Invest Med. 2016 Jun;64(5):1016-1024 ELISA Human Serum

Overexpression of serum sST2 is associated with poor prognosis in acute-on-chronic hepatitis B liver failure. Clinics and Research in Hepatology and Gastroenterology 2014 Nov 11 ELISA Human serum

Increased soluble ST2 and IL‑4 serum levels are associated with disease severity in patients with membranous nephropathy. Molecular Medicine Reports 2017 Nov 22 ELISA Human Serum

Relevance of serum interleukin-33 and ST2 levels and the natural course of chronic hepatitis B virus infection. BMC INFECTIOUS DISEASES 2016 May 16 ELISA Human Sera

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