IL-27A Polyclonal Antibody

  • Catalog No.：YT5975
  • Applications：IHC;IF;ELISA
  • Reactivity：Human;Mouse;Rat
    • Target：
    • IL-27A
    • Fields：
    • >>Cytokine-cytokine receptor interaction;>>Th17 cell differentiation
    • Gene Name：
    • IL27 IL27A
    • Protein Name：
    • Interleukin-27 subunit alpha (IL-27 subunit alpha) (IL-27-A) (IL27-A) (p28)
    • Human Swiss Prot No：
    • Q8NEV9
    • Mouse Swiss Prot No：
    • Q8K3I6
    • Immunogen：
    • Synthetic peptide from human protein at AA range: 1-50
    • Specificity：
    • The antibody detects endogenous IL-27A
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Interleukin-27 subunit alpha (IL-27 subunit alpha;IL-27-A;IL27-A;p28)
    • Background：
    • The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008],
    • Function：
    • function:Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct
    • Subcellular Location：
    • Secreted . Does not seem to be secreted without coexpression of EBI3.
    • Expression：
    • Expressed in monocytes and in placenta.

    Attributes

    • Code：
    • YT5975
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-09-06
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