• Target：
• NNT-1

• Fields：
• >>Cytokine-cytokine receptor interaction

• Gene Name：
• CLCF1 BSF3 CLC NNT1

• Protein Name：
• Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)

• Human Gene Id：
• 23529

• Human Swiss Prot No：
• Q9UBD9

• Mouse Gene Id：
• 56708

• Mouse Swiss Prot No：
• Q9QZM3

• Immunogen：
• Synthetic peptide from human protein at AA range: 171-220

• Specificity：
• The antibody detects endogenous NNT-1

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3;BSF-3;Novel neurotrophin-1;NNT-1)

• Background：
• This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encodin

• Function：
• disease:Defects in CLCF1 are the cause of cold-induced sweating syndrome 2 (CISS2) [MIM:610313]. Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.,function:Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.,similarity:Belongs to the IL-6 superfamily.,tissue specificity:Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.,

• Subcellular Location：
• Secreted .

• Expression：
• Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.

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