CD204 Polyclonal Antibody

  • Catalog No.：YT5947
  • Applications：IHC;IF;ELISA
  • Reactivity：Human;Mouse;Rat
    • Target：
    • CD204
    • Fields：
    • >>Phagosome
    • Gene Name：
    • MSR1 SCARA1
    • Protein Name：
    • Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204)
    • Human Gene Id：
    • 4481
    • Human Swiss Prot No：
    • P21757
    • Mouse Swiss Prot No：
    • P30204
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from the Internal region of human MSR1. AA range:241-290
    • Specificity：
    • The antibody detects endogenous CD204
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II;Scavenger receptor class A member 1;CD antigen CD204)
    • Background：
    • This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type
    • Function：
    • function:Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 SRCR domain.,subunit:Homotrimer.,tissue specificity:Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.,
    • Subcellular Location：
    • Membrane; Single-pass type II membrane protein.
    • Expression：
    • Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain.

    Attributes

    • Code：
    • YT5947
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-09-06
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