• Target：
• BMP-2

• Fields：
• >>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Pathways in cancer;>>Basal cell carcinoma

• Gene Name：
• BMP2

• Protein Name：
• Bone morphogenetic protein 2

• Human Gene Id：
• 650

• Human Swiss Prot No：
• P12643

• Mouse Gene Id：
• 12156

• Mouse Swiss Prot No：
• P21274

• Rat Gene Id：
• 29373

• Rat Swiss Prot No：
• P49001

• Immunogen：
• Synthesized peptide derived from Bone morphogenetic protein 2 at AA range: 341-390

• Specificity：
• BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IF 1:50-200 WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BMP2;BMP2A;Bone morphogenetic protein 2;BMP-2;Bone morphogenetic protein 2A;BMP-2A

• Observed Band(KD)：
• 44kD

• Background：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016],

• Function：
• function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.,

• Subcellular Location：
• Secreted.

• Expression：
• Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress.. Aging-US Aging-Us. 2020 May 31; 12(10): 9000–9013 WB Mouse 1:500 C3H10T1/2 cells

Chen, Rui, et al. "Activation of CD137 Signaling Enhances Vascular Calcification through c-Jun N-Terminal Kinase-Dependent Disruption of Autophagic Flux." Mediators of inflammation 2018 (2018).

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