• Target：
• BMP-15

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Ovarian steroidogenesis

• Gene Name：
• BMP15

• Protein Name：
• Bone morphogenetic protein 15

• Human Gene Id：
• 9210

• Human Swiss Prot No：
• O95972

• Mouse Gene Id：
• 12155

• Mouse Swiss Prot No：
• Q9Z0L4

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human BMP15. AA range:291-340

• Specificity：
• BMP-15 Polyclonal Antibody detects endogenous levels of BMP-15 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC: 100-300.WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BMP15;GDF9B;Bone morphogenetic protein 15;BMP-15;Growth/differentiation factor 9B;GDF-9B

• Observed Band(KD)：
• 45kD

• Background：
• This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016],

• Function：
• disease:Defects in BMP15 are the cause of ovarian dysgenesis 2 (ODG2) [MIM:300510]; also called X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Hypergonadotropic ovarian failure is a heterogeneous disorder that, in the most severe forms, is a result of ovarian dysgenesis (OD) or ovarian defective development. OD accounts for about half of the cases of primary amenorrhea.,function:May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.,miscellaneous:The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked.,

• Subcellular Location：
• Secreted.

Comparison and investigation on characteristics of polycystic ovary syndrome rat models induced by letrozole, testosterone propionate, and high-fat diets REPRODUCTIVE BIOMEDICINE ONLINE Runan Hu IF Rat 1:300 ovarian tissue

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