• Target：
• Ebi3

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Th17 cell differentiation

• Gene Name：
• EBI3

• Protein Name：
• Interleukin-27 subunit beta

• Human Gene Id：
• 10148

• Human Swiss Prot No：
• Q14213

• Mouse Gene Id：
• 50498

• Mouse Swiss Prot No：
• O35228

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human EBI3. AA range:101-150

• Specificity：
• Ebi3 Polyclonal Antibody detects endogenous levels of Ebi3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EBI3;IL27B;Interleukin-27 subunit beta;IL-27 subunit beta;IL-27B;Epstein-Barr virus-induced gene 3 protein;EBV-induced gene 3 protein

• Observed Band(KD)：
• 25kD

• Background：
• This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008],

• Function：
• function:Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.,induction:By EBV.,online information:Interleukin-27 entry,similarity:Belongs to the

• Subcellular Location：
• Secreted .

• Expression：
• B-cell,Pancreas,

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