CD206 Polyclonal Antibody

    • Catalog No.:YT5640
    • Applications:WB,IHC-p,IF(paraffin section),ELISA
    • Reactivity:Human,Mouse
      • Gene Name:
      • MRC1
      • Protein Name:
      • Macrophage mannose receptor 1
      • Human Gene Id:
      • 4360
      • Human Swiss Prot No:
      • P22897
      • Mouse Swiss Prot No:
      • Q61830
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from the Internal region of human MRC1. AA range:341-390
      • Specificity:
      • CD206 Polyclonal Antibody detects endogenous levels of CD206 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • IF(paraffin section) 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • MRC1; CLEC13D; CLEC13DL; MRC1L1; Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD206
      • MolecularWeight(Da):
      • 166012
      • Observed Band(KD):
      • 170
      • Background:
      • mannose receptor, C type 1(MRC1) Homo sapiens The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],
      • Function:
      • function:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,
      • Subcellular Location:
      • plasma membrane,integral component of plasma membrane,cell surface,endosome membrane,
      • Expression:
      • Milk,Placenta,Testis,
      • Products Images
      • Western Blot analysis of NIH-3T3 cells using CD206 Polyclonal Antibody.. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Western Blot analysis of 3T3 cells using CD206 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200