• Target：
• CD206

• Fields：
• >>Phagosome;>>Tuberculosis

• Gene Name：
• MRC1

• Protein Name：
• Macrophage mannose receptor 1

• Human Gene Id：
• 4360

• Human Swiss Prot No：
• P22897

• Mouse Gene Id：
• 17533

• Mouse Swiss Prot No：
• Q61830

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human MRC1. AA range:341-390

• Specificity：
• CD206 Polyclonal Antibody detects endogenous levels of CD206 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MRC1;CLEC13D;CLEC13DL;MRC1L1;Macrophage mannose receptor 1;MMR;C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;Macrophage mannose receptor 1-like protein 1;CD206

• Observed Band(KD)：
• 170kD

• Background：
• The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],

• Function：
• function:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains.,

• Subcellular Location：
• Endosome membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Milk,Placenta,Testis,

Mechanical loading mitigates osteoarthritis symptoms by regulating the inflammatory microenvironment in a mouse model 2022 Feb 27. WB Mouse articular cartilage

Mannosylated polydopamine nanoparticles alleviate radiation- induced pulmonary fibrosis by targeting M2 macrophages and inhibiting the TGF-β1/Smad3 signaling pathway. Yuhui Hao IF Mouse lung tissue bone marrow-derived macrophages (BMDM)

Bruton’s tyrosine kinase-bearing B cells and microglia in neuromyelitis optica spectrum disorder Journal of Neuroinflammation Liu Ye IF Mouse 1:200 brain tissue

STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation INFLAMMATION Wang Yue IF Mouse 1:50 hippocampal tissue

Targeted lung therapy with rosmarinic acid encapsulated in PLGA microspheres for radiation-induced pulmonary fibrosis JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY Yonglai Chen IHC Mouse 1:200 Lung tissue

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