• Target：
• CD192

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway

• Gene Name：
• CCR2

• Protein Name：
• C-C chemokine receptor type 2

• Human Gene Id：
• 729230

• Human Swiss Prot No：
• P41597

• Mouse Gene Id：
• 12772

• Mouse Swiss Prot No：
• P51683

• Rat Gene Id：
• 60463

• Rat Swiss Prot No：
• O55193

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR2. AA range:1-50

• Specificity：
• CD192 Polyclonal Antibody detects endogenous levels of CD192 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CCR2;CMKBR2;C-C chemokine receptor type 2;C-C CKR-2;CC-CKR-2;CCR-2;CCR2;Monocyte chemoattractant protein 1 receptor;MCP-1-R;CD192

• Observed Band(KD)：
• 42kD

• Background：
• This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009],

• Function：
• function:Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.,online information:CC chemokine receptors entry,polymorphism:Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].,PTM:N-glycosylated.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Binds to HIV-1 Tat.,

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. .

• Expression：
• Expressed by monocytes and IL2-activated NK cells.

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