Integrin αL Polyclonal Antibody

    • Catalog No.:YT5578
    • Applications:WB;ELISA
    • Reactivity:Human;Mouse
      • Target:
      • Integrin αL
      • Fields:
      • >>Rap1 signaling pathway;>>Cell adhesion molecules;>>Neutrophil extracellular trap formation;>>Natural killer cell mediated cytotoxicity;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Malaria;>>Staphylococcus aureus infection;>>Human T-cell leukemia virus 1 infection;>>Epstein-Barr virus infection;>>Rheumatoid arthritis;>>Viral myocarditis
      • Gene Name:
      • ITGAL
      • Protein Name:
      • Integrin alpha-L
      • Human Gene Id:
      • 3683
      • Human Swiss Prot No:
      • P20701
      • Mouse Swiss Prot No:
      • P24063
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from the Internal region of human ITGAL. AA range:171-220
      • Specificity:
      • Integrin αL Polyclonal Antibody detects endogenous levels of Integrin αL protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • ITGAL;CD11A;Integrin alpha-L;CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;LFA-1A;Leukocyte function-associated molecule 1 alpha chain;CD11a
      • Observed Band(KD):
      • 130kD
      • Background:
      • integrin subunit alpha L(ITGAL) Homo sapiens ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
      • Function:
      • domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.,tissue specificity:Leukocytes.,
      • Subcellular Location:
      • Cell membrane ; Single-pass type I membrane protein .
      • Expression:
      • Leukocytes.
      • Products Images
      • Western Blot analysis of 293 cells using Integrin αL Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000