Bag-3 Polyclonal Antibody

  • Catalog No.：YT5544
  • Applications：WB;IHC;IF;ELISA
  • Reactivity：Human;Mouse
    • Target：
    • Bag-3
    • Gene Name：
    • BAG3
    • Protein Name：
    • BAG family molecular chaperone regulator 3
    • Human Gene Id：
    • 9531
    • Human Swiss Prot No：
    • O95817
    • Mouse Swiss Prot No：
    • Q9JLV1
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from the Internal region of human BAG3. AA range:311-360
    • Specificity：
    • Bag-3 Polyclonal Antibody detects endogenous levels of Bag-3 protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • BAG3;BIS;BAG family molecular chaperone regulator 3;BAG-3;Bcl-2-associated athanogene 3;Bcl-2-binding protein Bis;Docking protein CAIR-1
    • Observed Band(KD)：
    • 80kD
    • Background：
    • BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],
    • Function：
    • function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.,similarity:Contains 1 BAG domain.,similarity:Contains 2 WW domains.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones. Binds to Bcl-2 and PLC-gamma.,
    • Subcellular Location：
    • Nucleus . Cytoplasm . Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920). .
    • Expression：
    • Brain,Epithelium,Liver,Lung,Placenta,T-cell,Testis,Tongue,

    Attributes

    • Code：
    • YT5544
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-11-24
    Order

    Related Products