FOXP3 Polyclonal Antibody

    • Catalog No.:YT5446
    • Applications:WB;IHC-p;IF(paraffin section);ELISA
    • Reactivity:Human;Mouse;Rat
      • Fields:
      • >>Th17 cell differentiation;>>Inflammatory bowel disease
      • Gene Name:
      • FOXP3
      • Protein Name:
      • Forkhead box protein P3
      • Human Swiss Prot No:
      • Q9BZS1
      • Mouse Swiss Prot No:
      • Q99JB6
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP3. AA range:381-430
      • Specificity:
      • FOXP3 Polyclonal Antibody detects endogenous levels of FOXP3 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • FOXP3; IPEX; JM2; Forkhead box protein P3; Scurfin
      • Observed Band(KD):
      • 47kD
      • Background:
      • The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
      • Function:
      • disease:Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.,function:Probable transcription factor. Plays a critical role in the control of immune response.,online information:FOXP3 entry,online information:FOXP3 mutation db,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,
      • Subcellular Location:
      • Nucleus . Cytoplasm . Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). .
      • Products Images
      • Western Blot analysis of PC12 cells using FOXP3 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Immunohistochemical analysis of paraffin-embedded human-tonsilla, antibody was diluted at 1:100
      • Immunohistochemical analysis of paraffin-embedded human-tonsilla, antibody was diluted at 1:100
      • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:100
      • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:100
      • Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:100