• Target：
• Eotaxin

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>IL-17 signaling pathway;>>Asthma

• Gene Name：
• CCL11

• Protein Name：
• Eotaxin

• Human Gene Id：
• 6356

• Human Swiss Prot No：
• P51671

• Mouse Gene Id：
• 20292

• Mouse Swiss Prot No：
• P48298

• Rat Gene Id：
• 29397

• Rat Swiss Prot No：
• P97545

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human CCL11. AA range:41-90

• Specificity：
• Eotaxin Polyclonal Antibody detects endogenous levels of Eotaxin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CCL11;SCYA11;Eotaxin;C-C motif chemokine 11;Eosinophil chemotactic protein;Small-inducible cytokine A11

• Observed Band(KD)：
• 11kD

• Background：
• This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014],

• Function：
• function:In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.,induction:By TNF-alpha, interleukin-1 alpha and interferon gamma.,online information:CCL11 entry,PTM:O-linked glycan consists of a Gal-GalNAc disaccharide which is mofified with up to 2 sialic acid residues.,similarity:Belongs to the intercrine beta (chemokine CC) family.,

• Subcellular Location：
• Secreted .

• Expression：
• Blood,Foreskin,Lung,Placenta,Small intestine,

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