CD71/TfR Polyclonal Antibody

    • Catalog No.：YT5374
    • Applications：WB;IHC;IF;ELISA
    • Reactivity：Human
      • Target：
      • CD71/TfR
      • Fields：
      • >>HIF-1 signaling pathway;>>Endocytosis;>>Phagosome;>>Ferroptosis;>>Hematopoietic cell lineage
      • Gene Name：
      • TFRC
      • Protein Name：
      • Transferrin receptor protein 1
      • Human Gene Id：
      • 7037
      • Human Swiss Prot No：
      • P02786
      • Mouse Swiss Prot No：
      • Q62351
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from the N-terminal region of human TFRC. AA range:101-150
      • Specificity：
      • CD71 Polyclonal Antibody detects endogenous levels of CD71 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • TFRC;Transferrin receptor protein 1;TR;TfR;TfR1;Trfr;T9;p90;CD71
      • Observed Band(KD)：
      • 85kD
      • Background：
      • This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],
      • Function：
      • function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use t
      • Subcellular Location：
      • Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Transferrin receptor protein 1, serum form]: Secreted .
      • Expression：
      • Brain,Epithelium,Erythroleukemia,Eye,Human endometrium carcinoma cell line,Liver,Pl
      • Products Images
      • Western Blot analysis of HuvEc cells using CD71 Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
      • Western blot analysis of lysate from HUVEC cells, using TFRC Antibody.

      Attributes

      • Code：
      • YT5374
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-07-24
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