CD71/TfR Polyclonal Antibody

  • Catalog No.：YT5374
  • Applications：WB;IHC;IF;ELISA
  • Reactivity：Human
    • Target：
    • CD71/TfR
    • Fields：
    • >>HIF-1 signaling pathway;>>Endocytosis;>>Phagosome;>>Ferroptosis;>>Hematopoietic cell lineage
    • Gene Name：
    • TFRC
    • Protein Name：
    • Transferrin receptor protein 1
    • Human Gene Id：
    • 7037
    • Human Swiss Prot No：
    • P02786
    • Mouse Swiss Prot No：
    • Q62351
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from the N-terminal region of human TFRC. AA range:101-150
    • Specificity：
    • CD71 Polyclonal Antibody detects endogenous levels of CD71 protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • TFRC;Transferrin receptor protein 1;TR;TfR;TfR1;Trfr;T9;p90;CD71
    • Observed Band(KD)：
    • 85kD
    • Background：
    • This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],
    • Function：
    • function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use t
    • Subcellular Location：
    • Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Transferrin receptor protein 1, serum form]: Secreted .
    • Expression：
    • Brain,Epithelium,Erythroleukemia,Eye,Human endometrium carcinoma cell line,Liver,Pl

    Attributes

    • Code：
    • YT5374
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-24
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