• Target：
• ARP

• Gene Name：
• MANF

• Protein Name：
• Mesencephalic astrocyte-derived neurotrophic factor

• Human Gene Id：
• 7873

• Human Swiss Prot No：
• P55145

• Mouse Swiss Prot No：
• Q9CXI5

• Rat Swiss Prot No：
• P0C5H9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human MANF. AA range:11-60

• Specificity：
• ARP Polyclonal Antibody detects endogenous levels of ARP protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MANF;ARMET;ARP;Mesencephalic astrocyte-derived neurotrophic factor;Arginine-rich protein;Protein ARMET

• Observed Band(KD)：
• 20kD

• Background：
• The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014],

• Function：
• response to unfolded protein, response to organic substance, response to protein stimulus,

• Subcellular Location：
• Secreted . Endoplasmic reticulum lumen . Sarcoplasmic reticulum lumen . Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475, PubMed:29497057). .

• Expression：
• Testis,

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