• Target：
• IL-28

• Fields：
• >>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway

• Gene Name：
• IL28A

• Protein Name：
• Interleukin-28A

• Human Gene Id：
• 282616

• Human Swiss Prot No：
• Q8IZJ0

• Mouse Gene Id：
• 330496

• Mouse Swiss Prot No：
• Q4VK74

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the C-terminal region of human IL28A. AA range:131-180

• Specificity：
• IL-28 Polyclonal Antibody detects endogenous levels of IL-28 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• IL28A;IFNL2;ZCYTO20;Interleukin-28A;IL-28A;Cytokine Zcyto20;Interferon lambda-2;IFN-lambda-2

• Observed Band(KD)：
• 25kD

• Background：
• This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008],

• Function：
• caution:It is uncertain whether Met-1 or Met-5 is the initiator.,function:Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.,induction:By viral infections or double stranded RNA.,online information:Interleukin-28 entry,similarity:Belongs to the IL-28/IL-29 family.,

• Subcellular Location：
• Secreted .

• Expression：
• Pooled,

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