• Target：
• CD116

• Fields：
• >>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>Pathways in cancer

• Gene Name：
• CSF2RA

• Protein Name：
• Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

• Human Gene Id：
• 1438

• Human Swiss Prot No：
• P15509

• Mouse Swiss Prot No：
• Q00941

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human CSF2RA. AA range:121-170

• Specificity：
• CD116 Polyclonal Antibody detects endogenous levels of CD116 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CSF2RA;CSF2R;CSF2RY;Granulocyte-macrophage colony-stimulating factor receptor subunit alpha;GM-CSF-R-alpha;GMCSFR-alpha;GMR-alpha;CDw116;CD116

• Observed Band(KD)：
• 44kD

• Background：
• The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008],

• Function：
• domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,

• Subcellular Location：
• Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted .; [Isoform 4]: Secreted .; [Isoform 6]: Secreted .

• Expression：
• Blood,Placenta,Synovial membrane tissue,Uterus,

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