• Target：
• Nectin 3

• Fields：
• >>Cell adhesion molecules;>>Adherens junction

• Gene Name：
• PVRL3

• Protein Name：
• Poliovirus receptor-related protein 3

• Human Gene Id：
• 25945

• Human Swiss Prot No：
• Q9NQS3

• Mouse Gene Id：
• 58998

• Mouse Swiss Prot No：
• Q9JLB9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human PVRL3. AA range:311-360

• Specificity：
• Nectin 3 Polyclonal Antibody detects endogenous levels of Nectin 3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PVRL3;PRR3;Poliovirus receptor-related protein 3;CDw113;Nectin-3;CD113

• Observed Band(KD)：
• 60kD

• Background：
• This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

• Function：
• function:Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR

• Subcellular Location：
• Cell membrane ; Single-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane .

• Expression：
• Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

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