• Target：
• MIP-1β

• Fields：
• >>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>NF-kappa B signaling pathway;>>Toll-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>Human cytomegalovirus infection

• Gene Name：
• CCL4

• Protein Name：
• C-C motif chemokine 4

• Human Gene Id：
• 388372

• Human Swiss Prot No：
• P13236

• Mouse Swiss Prot No：
• P14097

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human CCL4. AA range:41-90

• Specificity：
• MIP-1β Polyclonal Antibody detects endogenous levels of MIP-1β protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CCL4;LAG1;MIP1B;SCYA4;C-C motif chemokine 4;G-26 T-lymphocyte-secreted protein;HC21;Lymphocyte activation gene 1 protein;LAG-1;MIP-1-beta(1-69);Macrophage inflammatory protein 1-beta;MIP-1-beta;PAT 744;Protein H400;SIS-gamma;Small-inducible cytokine A4;T-cell activation protein 2;ACT-2

• Observed Band(KD)：
• 16kD

• Background：
• The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012],

• Function：
• alternative products:CCL4L1 and CCL4L2 genes differ in their non-coding regions. Thus, alternative splicing events differ between the two genes,caution:Was originally (PubMed:9521068) thought to be a ligand for CCR8.,function:Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.,function:Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR

• Subcellular Location：
• Secreted.

• Expression：
• Blood,Brain,Lung,Natural killer cell,T-cell,

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