• Target：
• TFPI-2

• Gene Name：
• TFPI2

• Protein Name：
• Tissue factor pathway inhibitor 2

• Human Gene Id：
• 7980

• Human Swiss Prot No：
• P48307

• Mouse Swiss Prot No：
• O35536

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the C-terminal region of human TFPI2. AA range:186-235

• Specificity：
• TFPI-2 Polyclonal Antibody detects endogenous levels of TFPI-2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TFPI2;Tissue factor pathway inhibitor 2;TFPI-2;Placental protein 5;PP5

• Observed Band(KD)：
• 13kD

• Background：
• This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

• Function：
• domain:This inhibitor contains three inhibitory domains.,function:May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,similarity:Contains 3 BPTI/Kunitz inhibitor domains.,tissue specificity:Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.,

• Subcellular Location：
• Secreted.

• Expression：
• Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.

Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells. Experimental and Therapeutic Medicine 2017 Aug 21 WB Human 1:5000 T24 cell

Feng, Chenchen, et al. "TFPI-2 expression is decreased in bladder cancer and is related to apoptosis." J BUON 21 (2016): 1518-1523.

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