• Target：
• LXRα

• Fields：
• >>PPAR signaling pathway;>>Insulin resistance;>>Non-alcoholic fatty liver disease;>>Hepatitis C

• Gene Name：
• NR1H3

• Protein Name：
• Oxysterols receptor LXR-alpha

• Human Gene Id：
• 10062

• Human Swiss Prot No：
• Q13133

• Mouse Gene Id：
• 22259

• Mouse Swiss Prot No：
• Q9Z0Y9

• Rat Swiss Prot No：
• Q62685

• Immunogen：
• The antiserum was produced against synthesized peptide derived from the Internal region of human NR1H3. AA range:151-200

• Specificity：
• LXRα Polyclonal Antibody detects endogenous levels of LXRα protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• NR1H3;LXRA;Oxysterols receptor LXR-alpha;Liver X receptor alpha;Nuclear receptor subfamily 1 group H member 3

• Observed Band(KD)：
• 50kD

• Background：
• The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

• Function：
• function:Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis.,induction:By 9-cis retinoic acid (9CRA).,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer of LXRA and RXR.,tissue specificity:Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.,

• Subcellular Location：
• Nucleus . Cytoplasm .

• Expression：
• Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.

Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology. Frontiers in Pharmacology Front Pharmacol. 2020 May;0:528 WB Golden hamster 1:1000 Liver

TO901317 inhibits the development of hepatocellular carcinoma by LXRα/Glut1 decreasing glycometabolism. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY Am J Physiol-Gastr L. 2019 May;316(5):G598-G607 WB,IHC Mouse,Human 1:100,1:1000 liver tissue,SMMC7721 cell xenografts SMMC7721 cell,HepG2 cell

RIP140 triggers foam‐cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor. FEBS LETTERS 2015 Jan 20 WB Human THP-1 macrophages

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