• Target：
• ATP1AL1

• Fields：
• >>Oxidative phosphorylation;>>Metabolic pathways

• Gene Name：
• ATP12A

• Protein Name：
• Potassium-transporting ATPase alpha chain 2

• Human Gene Id：
• 479

• Human Swiss Prot No：
• P54707

• Mouse Swiss Prot No：
• Q9Z1W8

• Rat Swiss Prot No：
• P54708

• Immunogen：
• Synthesized peptide derived from ATP1AL1 . at AA range: 380-460

• Specificity：
• ATP1AL1 Polyclonal Antibody detects endogenous levels of ATP1AL1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ATP12A;ATP1AL1;Potassium-transporting ATPase alpha chain 2;Non-gastric H(+)/K(+) ATPase subunit alpha;Proton pump

• Observed Band(KD)：
• 115kD

• Background：
• The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],

• Function：
• catalytic activity:ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).,function:Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.,subunit:Composed of two subunits: alpha (catalytic) and beta.,tissue specificity:Found in skin and kidney.,

• Subcellular Location：
• Apical cell membrane ; Multi-pass membrane protein .

• Expression：
• Expressed in airway epithelial cells (at protein level) (PubMed:29391451). Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level).

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