• Target：
• EEA1

• Fields：
• >>Endocytosis;>>Phagosome;>>Tuberculosis

• Gene Name：
• EEA1

• Protein Name：
• Early endosome antigen 1

• Human Gene Id：
• 8411

• Human Swiss Prot No：
• Q15075

• Mouse Gene Id：
• 216238

• Mouse Swiss Prot No：
• Q8BL66

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human EEA1. AA range:205-254

• Specificity：
• EEA1 Polyclonal Antibody detects endogenous levels of EEA1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• EEA1;ZFYVE2;Early endosome antigen 1;Endosome-associated protein p162;Zinc finger FYVE domain-containing protein 2

• Observed Band(KD)：
• 162kD

• Background：
• disease:Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases.,domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate.,function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 FYVE-type zinc finger.,subunit:Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.,

• Function：
• disease:Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases.,domain:The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate.,function:Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 FYVE-type zinc finger.,subunit:Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.,

• Subcellular Location：
• Cytoplasm. Early endosome membrane; Peripheral membrane protein.

• Expression：
• Aorta,Cervix carcinoma,Fetal brain cortex,Skeletal muscle,

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