• Target：
• XRCC2

• Fields：
• >>Homologous recombination

• Gene Name：
• XRCC2

• Protein Name：
• DNA repair protein XRCC2

• Human Gene Id：
• 7516

• Human Swiss Prot No：
• O43543

• Mouse Swiss Prot No：
• Q9CX47

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human XRCC2. AA range:211-260

• Specificity：
• XRCC2 Polyclonal Antibody detects endogenous levels of XRCC2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• XRCC2;DNA repair protein XRCC2;X-ray repair cross-complementing protein 2

• Observed Band(KD)：
• 32kD

• Background：
• This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008],

• Function：
• function:Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the recA family. RAD51 subfamily.,subunit:Interacts with RAD51D. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. In the absence of DNA, XRCC2-RAD51D formed a multimeric ring structure. In the presence of single-stranded DNA, XRCC2-RAD51D formed a filamentous structure.,

• Subcellular Location：
• Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .

• Expression：
• Brain,Cervix carcinoma,Testis,

c-Myc-XRCC2-FOS axis promotes the proliferation and the resistance to Doxorubicin of NSCLC BIOMEDICINE & PHARMACOTHERAPY Peihe Zhang IHC Mouse,Human 1:200 Non-small cell lung cancer tissue,A549 cell-Xenograft

XRCC2 driven homologous recombination subtypes and therapeutic targeting in lung adenocarcinoma metastasis npj Precision Oncology Gong Han IHC Mouse,Human 1:100 Lung adenocarcinoma (LUAD) tissue,A549 cell-Xenograft

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