• Target：
• XPLN

• Gene Name：
• ARHGEF3

• Protein Name：
• Rho guanine nucleotide exchange factor 3

• Human Gene Id：
• 50650

• Human Swiss Prot No：
• Q9NR81

• Mouse Gene Id：
• 71704

• Mouse Swiss Prot No：
• Q91X46

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ARHGEF3. AA range:456-505

• Specificity：
• XPLN Polyclonal Antibody detects endogenous levels of XPLN protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000.IHC:1:50-300 ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ARHGEF3;Rho guanine nucleotide exchange factor 3;Exchange factor found in platelets and leukemic and neuronal tissues;XPLN

• Observed Band(KD)：
• 55kD

• Background：
• Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

• Function：
• function:Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,subunit:Interacts with RHOA and RHOB.,tissue specificity:Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.

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