V-ATPase C2 Polyclonal Antibody

    • Catalog No.:YT4859
    • Applications:WB,ELISA
    • Reactivity:Human
      • Gene Name:
      • ATP6V1C2
      • Protein Name:
      • V-type proton ATPase subunit C 2
      • Human Swiss Prot No:
      • Q8NEY4
      • Mouse Swiss Prot No:
      • Q99L60
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human ATP6V1C2. AA range:121-170
      • Specificity:
      • V-ATPase C2 Polyclonal Antibody detects endogenous levels of V-ATPase C2 protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Rabbit
      • Dilution:
      • Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • ATP6V1C2; V-type proton ATPase subunit C 2; V-ATPase subunit C 2; Vacuolar proton pump subunit C 2
      • MolecularWeight(Da):
      • 48759
      • Observed Band(KD):
      • 48
      • Background:
      • ATPase H+ transporting V1 subunit C2(ATP6V1C2) Homo sapiens This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008],
      • Function:
      • function:Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.,similarity:Belongs to the V-ATPase C subunit family.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).,tissue specificity:Kidney and placenta.,
      • Subcellular Location:
      • vacuolar proton-transporting V-type ATPase, V1 domain,lysosomal membrane,cytosol,proton-transporting V-type ATPase, V1 domain,extracellular exosome,
      • Expression:
      • Eye,
      • Products Images
      • Western blot analysis of ATP6V1C2 Antibody. The lane on the right is blocked with the ATP6V1C2 peptide.
      • Western blot analysis of the lysates from HT-29 cells using ATP6V1C2 antibody.