TULA Polyclonal Antibody

    • Catalog No.:YT4782
    • Applications:WB;ELISA
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • TULA
      • Gene Name:
      • UBASH3A
      • Protein Name:
      • Ubiquitin-associated and SH3 domain-containing protein A
      • Human Swiss Prot No:
      • P57075
      • Mouse Swiss Prot No:
      • Q3V3E1
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human UBASH3A. AA range:311-360
      • Specificity:
      • TULA Polyclonal Antibody detects endogenous levels of TULA protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • UBASH3A;STS2;Ubiquitin-associated and SH3 domain-containing protein A;Cbl-interacting protein 4;CLIP4;Suppressor of T-cell receptor signaling 2;STS-2;T-cell ubiquitin ligand 1;TULA-1
      • Observed Band(KD):
      • 75kD
      • Background:
      • This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011],
      • Function:
      • function:Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 UBA domain.,subunit:Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins.,tissue specificity:Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.,
      • Subcellular Location:
      • Cytoplasm. Nucleus.
      • Expression:
      • Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
      • Products Images
      • Western blot analysis of UBASH3A Antibody. The lane on the right is blocked with the UBASH3A peptide.