• Target：
• TULA

• Gene Name：
• UBASH3A

• Protein Name：
• Ubiquitin-associated and SH3 domain-containing protein A

• Human Gene Id：
• 53347

• Human Swiss Prot No：
• P57075

• Mouse Swiss Prot No：
• Q3V3E1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human UBASH3A. AA range:311-360

• Specificity：
• TULA Polyclonal Antibody detects endogenous levels of TULA protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• UBASH3A;STS2;Ubiquitin-associated and SH3 domain-containing protein A;Cbl-interacting protein 4;CLIP4;Suppressor of T-cell receptor signaling 2;STS-2;T-cell ubiquitin ligand 1;TULA-1

• Observed Band(KD)：
• 75kD

• Background：
• This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011],

• Function：
• function:Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 UBA domain.,subunit:Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins.,tissue specificity:Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.,

• Subcellular Location：
• Cytoplasm. Nucleus.

• Expression：
• Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.

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