• Target：
• TSC-22

• Gene Name：
• TSC22D1

• Protein Name：
• TSC22 domain family protein 1

• Human Gene Id：
• 8848

• Human Swiss Prot No：
• Q15714

• Mouse Gene Id：
• 21807

• Mouse Swiss Prot No：
• P62500

• Rat Gene Id：
• 498545

• Rat Swiss Prot No：
• P62501

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TSC22D1. AA range:71-120

• Specificity：
• TSC-22 Polyclonal Antibody detects endogenous levels of TSC-22 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TSC22D1;KIAA1994;TGFB1I4;TSC22;hucep-2;TSC22 domain family protein 1;Cerebral protein 2;Regulatory protein TSC-22;TGFB-stimulated clone 22 homolog;Transforming growth factor beta-1-induced transcript 4 protein

• Observed Band(KD)：
• 16kD

• Background：
• This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011],

• Function：
• function:Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.,induction:In aortic endothelial cells, induced by cytokines, including TGFB.,similarity:Belongs to the TSC-22/Dip/Bun family.,subunit:Homodimer or heterodimer. Can form an heterodimer with TSC22D4.,tissue specificity:Widely expressed in fetal and adult tissues.,

• Subcellular Location：
• Cytoplasm . Nucleus .

• Expression：
• Widely expressed in fetal and adult tissues.

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