TNNI3K Polyclonal Antibody

    • Catalog No.:YT4692
    • Applications:WB;IHC;IF;ELISA
    • Reactivity:Human;Mouse;Rat
      • Target:
      • TNNI3K
      • Gene Name:
      • TNNI3K
      • Protein Name:
      • Serine/threonine-protein kinase TNNI3K
      • Human Swiss Prot No:
      • Q59H18
      • Mouse Swiss Prot No:
      • Q5GIG6
      • Immunogen:
      • The antiserum was produced against synthesized peptide derived from human TNNI3K. AA range:301-350
      • Specificity:
      • TNNI3K Polyclonal Antibody detects endogenous levels of TNNI3K protein.
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000. IF 1:50-200
      • Purification:
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • TNNI3K;CARK;Serine/threonine-protein kinase TNNI3K;Cardiac ankyrin repeat kinase;Cardiac troponin I-interacting kinase;TNNI3-interacting kinase
      • Molecular Weight(Da):
      • 104kD
      • Background:
      • This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012],
      • Function:
      • catalytic activity:ATP + a protein = ADP + a phosphoprotein.,catalytic activity:GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.,cofactor:Magnesium.,function:Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.,function:May play a role in cardiac physiology.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 10 ANK repeats.,subcellular location:Expressed at lower levels in the cytoplasm.,subunit:Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.,tissue specificity:Expressed in many tissues.,tissue specificity:Highly expressed in both adult and fetal heart.,
      • Subcellular Location:
      • Nucleus . Cytoplasm . Expressed at lower levels in the cytoplasm.
      • Expression:
      • Highly expressed in both adult and fetal heart.
      • Products Images
      • Western blot analysis of Mouse-kidney lysis using TNNI3K antibody. Antibody was diluted at 1:500. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
      • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TNNI3K Antibody. The picture on the right is blocked with the synthesized peptide.