• Target：
• TIRAP

• Fields：
• >>NF-kappa B signaling pathway;>>Toll-like receptor signaling pathway;>>Alcoholic liver disease;>>Pathogenic Escherichia coli infection;>>Salmonella infection;>>Pertussis;>>Tuberculosis;>>Hepatitis B;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Lipid and atherosclerosis

• Gene Name：
• TIRAP

• Protein Name：
• Toll/interleukin-1 receptor domain-containing adapter protein

• Human Gene Id：
• 114609

• Human Swiss Prot No：
• P58753

• Mouse Gene Id：
• 117149

• Mouse Swiss Prot No：
• Q99JY1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TIRAP. AA range:52-101

• Specificity：
• TIRAP Polyclonal Antibody detects endogenous levels of TIRAP protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TIRAP;MAL;Toll/interleukin-1 receptor domain-containing adapter protein;TIR domain-containing adapter protein;Adaptor protein Wyatt;MyD88 adapter-like protein

• Molecular Weight(Da)：
• 24kD

• Background：
• The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],

• Function：
• function:Adapter involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, resulting in cytokine secretion and the inflammatory response.,polymorphism:Genetic variation in TIRAP can influence susceptibility or resistance to invasive pneumococcal disease, bacteremia, malaria and tuberculosi.,similarity:Contains 1 TIR domain.,subunit:Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9.,tissue specificity:Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.,

• Subcellular Location：
• Cytoplasm . Cell membrane . Membrane . Colocalizes with DAB2IP at the plasma membrane.

• Expression：
• Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.

Phycocyanin Exerts Anti-Proliferative Effects through Down-Regulating TIRAP/NF-κB Activity in Human Non-Small Cell Lung Cancer Cells. Cells Cells-Basel. 2019 Jun;8(6):588 WB Human H1975 cell, H1650 cell,LTEP-a2 cell

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