• Target：
• TIEG2

• Gene Name：
• KLF11

• Protein Name：
• Krueppel-like factor 11

• Human Gene Id：
• 8462

• Human Swiss Prot No：
• O14901

• Mouse Gene Id：
• 194655

• Mouse Swiss Prot No：
• Q8K1S5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human KLF11. AA range:1-50

• Specificity：
• TIEG2 Polyclonal Antibody detects endogenous levels of TIEG2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• KLF11;FKLF;TIEG2;Krueppel-like factor 11;Transforming growth factor-beta-inducible early growth response protein 2;TGFB-inducible early growth response protein 2;TIEG-2

• Observed Band(KD)：
• 55kD

• Background：
• The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010],

• Function：
• caution:PubMed:11087666 sequence was originally thought to originate from mouse.,disease:Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7) [MIM:610508]. MODY [MIM:606391] has an autosomal dominant inheritance, onset at age less than 25 years and a primary defect in insulin secretion. MODY pedigrees are usually multigenerational families with penetrance of 80 to 95%. Patients have a nonobese body habitus and the so-called metabolic syndrome characterized by diabetes, insulin resistance, hypertension, and hypertriglyceridemia is absent.,function:Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.,induction:By TGF-beta.,s

• Subcellular Location：
• Nucleus .

• Expression：
• Ubiquitous. Higher expression in erythroid cells.

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