• Target：
• SURF-1

• Gene Name：
• SURF1

• Protein Name：
• Surfeit locus protein 1

• Human Gene Id：
• 6834

• Human Swiss Prot No：
• Q15526

• Mouse Gene Id：
• 20930

• Mouse Swiss Prot No：
• P09925

• Rat Gene Id：
• 64463

• Rat Swiss Prot No：
• Q9QXU2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SURF1. AA range:171-220

• Specificity：
• SURF-1 Polyclonal Antibody detects endogenous levels of SURF-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SURF1;SURF-1;Surfeit locus protein 1

• Observed Band(KD)：
• 30kD

• Background：
• This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in SURF1 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency.,function:Probably involved in the biogenesis of the COX complex.,similarity:Belongs to the SURF1 family.,

• Subcellular Location：
• Mitochondrion inner membrane ; Multi-pass membrane protein .

• Expression：
• Colon,Kidney,Skin,Stomach,

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