• Target：
• SSH3

• Fields：
• >>Axon guidance;>>Regulation of actin cytoskeleton

• Gene Name：
• SSH3

• Protein Name：
• Protein phosphatase Slingshot homolog 3

• Human Gene Id：
• 54961

• Human Swiss Prot No：
• Q8TE77

• Mouse Gene Id：
• 245857

• Mouse Swiss Prot No：
• Q8K330

• Rat Gene Id：
• 365396

• Rat Swiss Prot No：
• Q5XIS1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SSH3. AA range:357-406

• Specificity：
• SSH3 Polyclonal Antibody detects endogenous levels of SSH3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SSH3;SSH3L;Protein phosphatase Slingshot homolog 3;SSH-like protein 3;SSH-3L;hSSH-3L

• Observed Band(KD)：
• 74kD

• Background：
• The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008],

• Function：
• catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.,miscellaneous:Tyrosine phosphatase activity has not been demonstrated for this protein to date.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Does not bind to, or colocalize with, filamentous actin.,

• Subcellular Location：
• Cytoplasm, cytoskeleton . Nucleus .

• Expression：
• Cerebellum,Epithelium,Ovarian carcinoma,Uterus,

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