• Target：
• SR-6

• Fields：
• >>Calcium signaling pathway;>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Serotonergic synapse

• Gene Name：
• HTR6

• Protein Name：
• 5-hydroxytryptamine receptor 6

• Human Gene Id：
• 3362

• Human Swiss Prot No：
• P50406

• Mouse Gene Id：
• 15565

• Mouse Swiss Prot No：
• Q9R1C8

• Rat Gene Id：
• 64354

• Rat Swiss Prot No：
• P31388

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human 5-HT-6. AA range:221-270

• Specificity：
• SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• HTR6;5-hydroxytryptamine receptor 6;5-HT-6;5-HT6;Serotonin receptor 6

• Observed Band(KD)：
• 47kD

• Background：
• This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013],

• Function：
• function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in several human brain regions, most prominently in the caudate nucleus.,

• Subcellular Location：
• Cell membrane; Multi-pass membrane protein.

• Expression：
• Expressed in several human brain regions, most prominently in the caudate nucleus.

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