• Target：
• SR-2B

• Fields：
• >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Serotonergic synapse;>>Inflammatory mediator regulation of TRP channels

• Gene Name：
• HTR2B

• Protein Name：
• 5-hydroxytryptamine receptor 2B

• Human Gene Id：
• 3357

• Human Swiss Prot No：
• P41595

• Mouse Swiss Prot No：
• Q02152

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human HTR2B. AA range:15-64

• Specificity：
• SR-2B Polyclonal Antibody detects endogenous levels of SR-2B protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• HTR2B;5-hydroxytryptamine receptor 2B;5-HT-2B;5-HT2B;Serotonin receptor 2B

• Observed Band(KD)：
• 54kD

• Background：
• This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016],

• Function：
• function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with MPDZ.,tissue specificity:Detected in most peripheral organs. Only low expression levels were found in the brain.,

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .

• Expression：
• Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.

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