• Target：
• SR-2A

• Fields：
• >>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Gap junction;>>Serotonergic synapse;>>Inflammatory mediator regulation of TRP channels

• Gene Name：
• HTR2A

• Protein Name：
• 5-hydroxytryptamine receptor 2A

• Human Gene Id：
• 3356

• Human Swiss Prot No：
• P28223

• Mouse Swiss Prot No：
• P35363

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human 5-HT-2A. AA range:422-471

• Specificity：
• SR-2A Polyclonal Antibody detects endogenous levels of SR-2A protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• HTR2A;HTR2;5-hydroxytryptamine receptor 2A;5-HT-2;5-HT-2A;Serotonin receptor 2A

• Molecular Weight(Da)：
• 53kD

• Background：
• This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],

• Function：
• domain:The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localizes to the post-synaptic thickening of axo-dendritic synapses.,subunit:Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2.,

• Subcellular Location：
• Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cytoplasmic vesicle . Membrane, caveola . Cell junction, synapse, presynapse .

• Expression：
• Detected in brain cortex (at protein level). Detected in blood platelets.

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