• Target：
• SLC6A8

• Gene Name：
• SLC6A8

• Protein Name：
• Sodium- and chloride-dependent creatine transporter 1

• Human Gene Id：
• 6535

• Human Swiss Prot No：
• P48029

• Mouse Gene Id：
• 102857

• Mouse Swiss Prot No：
• Q8VBW1

• Rat Gene Id：
• 50690

• Rat Swiss Prot No：
• P28570

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SLC6A8. AA range:581-630

• Specificity：
• SLC6A8 Polyclonal Antibody detects endogenous levels of SLC6A8 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SLC6A8;Sodium- and chloride-dependent creatine transporter 1;CT1;Creatine transporter 1;Solute carrier family 6 member 8

• Observed Band(KD)：
• 70kD

• Background：
• The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],

• Function：
• disease:Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome [MIM:300352]. X-linked creatine deficiency syndrome causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia.,function:Required for the uptake of creatine in muscles and brain.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,tissue specificity:Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate.,

• Subcellular Location：
• Membrane; Multi-pass membrane protein.

• Expression：
• Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate.

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