SIRT3 Polyclonal Antibody

  • Catalog No.：YT4304
  • Applications：WB;ELISA
  • Reactivity：Human;Mouse;
    • Target：
    • SIRT3
    • Fields：
    • >>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Central carbon metabolism in cancer
    • Gene Name：
    • SIRT3
    • Protein Name：
    • NAD-dependent protein deacetylase sirtuin-3 mitochondrial
    • Human Swiss Prot No：
    • Q9NTG7
    • Mouse Swiss Prot No：
    • Q8R104
    • Immunogen：
    • The antiserum was produced against synthesized peptide derived from human SIRT3. AA range:350-399
    • Specificity：
    • SIRT3 Polyclonal Antibody detects endogenous levels of SIRT3 protein.
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
    • Purification：
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • SIRT3;SIR2L3;NAD-dependent protein deacetylase sirtuin-3; mitochondrial;hSIRT3;Regulatory protein SIR2 homolog 3;SIR2-like protein 3
    • Observed Band(KD)：
    • 45kD
    • Background：
    • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008],
    • Function：
    • catalytic activity:NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.,cofactor:Binds 1 zinc ion per subunit.,function:NAD-dependent deacetylase. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.,PTM:Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.,similarity:Belongs to the sirtuin family.,similarity:Contains 1 deacetylase sirtuin-type domain.,tissue specificity:Widely expressed.,
    • Subcellular Location：
    • Mitochondrion matrix .
    • Expression：
    • Widely expressed.

    Attributes

    • Code：
    • YT4304
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 150 / 280 / 450
    • Delivery：
    • 2024-12-22
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