• Target：
• SF-1

• Fields：
• >>Cortisol synthesis and secretion;>>Cushing syndrome

• Gene Name：
• NR5A1

• Protein Name：
• Steroidogenic factor 1

• Human Gene Id：
• 2516

• Human Swiss Prot No：
• Q13285

• Mouse Gene Id：
• 26423

• Mouse Swiss Prot No：
• P33242

• Rat Gene Id：
• 83826

• Rat Swiss Prot No：
• P50569

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human NR5A1. AA range:169-218

• Specificity：
• SF-1 Polyclonal Antibody detects endogenous levels of SF-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• NR5A1;AD4BP;FTZF1;SF1;Steroidogenic factor 1;SF-1;STF-1;Adrenal 4-binding protein;Fushi tarazu factor homolog 1;Nuclear receptor subfamily 5 group A member 1;Steroid hormone receptor Ad4BP

• Observed Band(KD)：
• 50kD

• Background：
• The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in NR5A1 are a cause of adrenocortical insufficiency without ovarian defect [MIM:184757]. The disease is characterized by severe 'slackness,' muscular hypotonia. There is decreased sodium, increased potassium and elevated ACTH.,disease:Defects in NR5A1 are a cause of XY sex reversal with or without adrenal failure [MIM:184757]. This disease is characterized by normal female external genitalia and retention of the uterus.,function:Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NO

• Subcellular Location：
• Nucleus .

• Expression：
• High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385).

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